Heterochromatin and DNA damage repair: Use different histone variants and relax
نویسندگان
چکیده
منابع مشابه
The DNA damage response in chromatin: a focus on histone variants and heterochromatin proteins
The view of DNA packaging into chromatin as a mere obstacle to DNA repair is evolving. In this review, we focus on histone variants and heterochromatin proteins as chromatin components involved in distinct levels of chromatin organization to integrate them as real players in the DNA damage response (DDR). Based on recent data, we highlight how some of these chromatin components play active role...
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Histone/protein deacetylases play multiple roles in regulating gene expression and protein activation and stability. Their deregulation during cancer initiation and progression cause resistance to therapy. Here, we review the role of histone deacetylases (HDACs) and the NAD+ dependent sirtuins (SIRTs) in the DNA damage response (DDR). These lysine deacetylases contribute to DNA repair by base e...
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DNA damage, repair and mutations Harry Vrieling Introduction DNA contains the blueprint for the proper development, functioning and reproduction of organisms ranging from bacteria, low eukaryotes to vertebrates like man. It is therefore of extreme importance that both replication, i.e. the duplication of DNA, and the segregation of fully replicated DNA molecules (i.e. the chromosomes) over the ...
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ژورنال
عنوان ژورنال: Nucleus
سال: 2017
ISSN: 1949-1034,1949-1042
DOI: 10.1080/19491034.2017.1384893